KARAKTERISTIK KARSINOMA PARU BUKAN SEL KECIL DAN HASIL PEMERIKSAAN EGFR DI RSUP DR. HASAN SADIKIN PERIODE TAHUN 2018-2020
Abstract
Karsinoma paru adalah keganasan akibat pertumbuhan baru dari sel epitel paru yang abnormal. Karsinoma paru diklasifikasikan menjadi dua tipe; Kanker Paru Karsinoma Bukan Sel Kecil dan Kanker Paru Karsinoma Sel Kecil. Tipe KPKBSK ditemukan sebanyak 85% dari kasus karsinoma paru. Pada KPKBSK sering ditemukan overekspresi EGFR. Tujuan penelitian ini untuk mengetahui karakteristik pasien, status merokok, status fungsional, stadium klinis, diagnosis histopatologi, dan hasil pemeriksaan EGFR dari KPKBSK di RSUP Dr. Hasan Sadikin Bandung periode tahun 2018-2020. Penelitian ini merupakan penelitian deskriptif dengan subjek penelitian rekam medis pasien yang didiagnosis KPKBSK. Data diambil dengan metode total sampling. Dari 67 kasus KPKBSK, pasien KPKBSK paling banyak ditemukan pada kelompok usia 55-64 tahun (31,3%). Jenis kelamin terbanyak adalah laki laki (62,7%). KPKBSK lebih banyak didapatkan pada pasien bukan perokok (83,6%). Status fungsional dari pasien KPKBSK yang terbanyak adalah “sangat tergantung” (46,3%). Stadium klinis pasien KPKBSK yang terbanyak adalah stadium IV (97%). Diagnosis histopatologi KPKBSK yang terbanyak adalah adenokarsinoma (67,2%). Sebagian besar penderita KPKBSK di RSUP Dr. Hasan Sadikin Bandung tidak menjalani pemeriksaan EGFR (80,6%). Pasien yang dilakukan pemeriksaan EGFR hasil yang terbanyak adalah negatif (9%). Subtipe tumor dengan hasil pemeriksaan EGFR yang positif dan negatif seluruhnya adalah subtipe adenokarsinoma. Simpulan dari penelitian ini, karakteristik KPKBSK adalah usia 55-64 tahun, jenis kelamin laki-laki, bukan perokok, status fungsional pasien “sangat tergantung”, stadium klinis IV, diagnosis histopatologi adenokarsinoma, dan hasil pemeriksaan EGFR negatif. Overekspresi EGFR pada KPKBSK terjadi akibat mutasi somatik pada domain tirosin kinase menyebabkan transduksi sinyal dan proses fosforilasi yang terus menerus.
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15. Putra DN, W Laksmi, Mustokoweni S. Profil Penderita Karsinoma Paru Karsinoma Bukan Sel Kecil (KPKBSK) Di RSUD Dr. Soetomo. Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga 2016;8(1): 30-34.
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31. Wee P, Wang Z. Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways. Cancers 2017;9(52): 1-45.
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i/2017/1809513/ (16 January 2017) [accessed July 12th 2021].
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35. Ahyati SN, Oktaviyanti IK, Yuliana I. Hubungan Jenis Kelamin dan Riwayat Merokok dengan Mutasi Gen EGFR Karsinoma Paru Tipe Adenokarsinoma.
Homeostasis 2019;2(1): 1-8.
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37. Reynaldi A, et al. Kualitas Hidup Pasien Kanker Paru Stadium Lanjut. JNC 2020;3(2): 71-78.
38. Neo J, et al. Disability in Activities of Daily Living Among Adults With Cancer: A Systematic Review and Meta-Analysis. Elsevier: Cancer Treatment Reviews 2017;94-106.
39. Gridelli C, et al. Chemotherapy for Elderly Patients With Advanced Non-Small-Cell Lung Cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) Phase III Randomized Trial. Journal of the National Cancer Institute 2013; 95(5): 362-372
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44. Ichsan M.I, et al. Hubungan Kadar Carcinoembryonic Antigen (CEA) dengan Subtipe Histologi Kanker Paru di RSUD Abdul Wahab Sjahranie Samarinda. Jurnal Kedokteran Mulawarman 2020;7(3): 23-30.
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46. Oktaviyanti I.K. Mutasi EGFR Pada Pemeriksaan Sitologi Adenokarsinoma Paru. Berkala Kedokteran 2015:11(2): 213-219.
47. Kumari N, et al. Epidermal Growth Factor Receptor Mutation Frequency in Squamous Cell Carcinoma and Its Diagnostic Performance in Cytological Samples: A Molecular and Immunohistochemical Study. World J Oncol 2019;10(3): 142-150.
Published
2022-06-30
How to Cite
KOSWARA, Teja; IRIAWAN, Jusron; SURYA, Fiona.
KARAKTERISTIK KARSINOMA PARU BUKAN SEL KECIL DAN HASIL PEMERIKSAAN EGFR DI RSUP DR. HASAN SADIKIN PERIODE TAHUN 2018-2020.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 5, n. 2, p. 150-161, june 2022.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/434>. Date accessed: 26 apr. 2024.
Section
Articles
