PAPARAN PARAKUAT TERHADAP REGULASI PROTEIN APOPTOSIS NEURON PADA SUBSTANTIA NIGRA MODEL PARKINSON: TINJAUAN SISTEMATIK
Abstract
Parakuat adalah herbisida yang berfungsi untuk mengendalikan gulma dan sering digunakan di Indonesia. Parakuat merupakan faktor risiko penyakit Parkinson. Parakuat mampu menimbulkan apoptosis neuron pada model Parkinson, namun pernyataan tersebut masih menjadi perdebatan. Hal tersebut mendorong dilakukannya kajian sistematik mengenai paparan parakuat terhadap regulasi protein apoptosis neuron pada substantia nigra model Parkinson. Tujuan penelitian ini adalah mengetahui pengaruh paparan parakuat terhadap regulasi protein apoptosis neuron pada substantia nigra model Parkinson. Pencarian artikel didapatkan dari empat basis data, yaitu PubMed, Science Direct, Nature, dan GARUDA. Outcome yang dinilai adalah protein apoptosis neuron menggunakan analisis kualitas serta risiko bias SYRCLE tools dan didapatkan lima studi eksperimental in vivo dengan risiko bias rendah. Satu artikel menunjukkan tidak adanya apoptosis neuron dan empat artikel menunjukkan adanya apoptosis neuron dengan bukti peningkatan protein pro-apoptosis bax, P-p53, sitokrom c, kaspase-9, dan kaspase-3 yang merupakan jalur intrinsik apoptosis neuron.
Kata kunci: parakuat, parkinson, protein apoptosis
References
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20. Franco R, Li S, Rodriguez-Rocha H. Molecular Mechanisms of Pesticide-induced Neurotoxicity: Relevance to Parkinson’s Disease. Fieldiana Geol. 2010;289–300.
2. Mutiarahmi CN, Hartady T, Lesmana R. Use of Mice As Experimental Animals in Laboratories That Refer To the Principles of Animal Welfare: a Literature Review. Indones Med Veterinus. 2021;10(1):134–45.
3. Yudaniayanti IS, Maulana E, Ma’ruf A. Profil Penggunaan Kombinasi Ketamin-Xylazine dan Ketamin-Midazolam Sebagai Anestesi Umum Terhadap Gambaran Fisiologis Tubuh pada Kelinci Jantan. Vet Med. 2010;3(1):23–30.
4. Kuncoro PT, Setyaningsih I, Was’an M. Peran α -synuclein sebagai target terapi parkinsonisme pasca cedera kepala. Berk Neurosains. 2020;19(1):28–34.
5. Bueno-Carrasco MT, Cuéllar J, Flydal MI, Santiago C, Kråkenes TA, Kleppe R, et al. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun. 2022;13(1):1–16.
6. Maiti P, Manna J, Dunbar GL, Maiti P, Dunbar GL. Current understanding of the molecular mechanisms in Parkinson’s disease: Targets for potential treatments. Transl Neurodegener. 2017;6(1):1–35.
7. Tanner CM, Kame F, Ross GW, Hoppin JA, Goldman SM, Korell M, et al. Rotenone, paraquat, and Parkinson’s disease. Environ Health Perspect. 2011;119(6):866–72.
8. Umiyati U, Widayat D, Salarti N. Efektivitas Herbisida Paraquat Diklorida 276 g/L sebagai Pengendali Gulma pada Tanaman Tebu (Saccharum officinarum L.). Agrosintesa J Ilmu Budid Pertan. 2018;1(1):37–44.
9. Hanriko R, Anzani BP. Penyakit Parkinson: Ancaman Kesehatan bagi Komunitas Pertanian. J Agromedicine. 2018;5(1):508–12.
10. Nandipati S, Litvan I. Environmental exposures and Parkinson’s disease. Int J Environ Res Public Health. 2016;13(9).
11. Baltazar MT, Dinis-Oliveira RJ, Bastos M, Tsatsakis AM, Duarte JA, Carvalho F. Pesticides exposure as etiological factors of Parkinson’s disease and other neurodegenerative diseases-A mechanistic approach. Toxicol Lett [Internet]. 2014;230(2):85–103. Available from: http://dx.doi.org/10.1016/j.toxlet.2014.01.039.
12. Srivastav S, Fatima M, Mondal AC. Bacopa monnieri alleviates paraquat induced toxicity in Drosophila by inhibiting jnk mediated apoptosis through improved mitochondrial function and redox stabilization. Neurochem Int [Internet]. 2018;121:98–107. Available from: https://doi.org/10.1016/j.neuint.2018.10.001.
13. Breckenridge CB, Sturgess NC, Butt M, Wolf JC, Zadory D, Beck M, et al. Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice. Neurotoxicology [Internet]. 2013;37:1–14. Available from: http://dx.doi.org/10.1016/j.neuro.2013.03.005.
14. Smeyne RJ, Breckenridge CB, Beck M. Assessment of the effects of MPTP and paraquat on dopaminergic neurons and microglia in the substantia nigra pars compacta of C57BL/6 mice. PLoS One. 2016;11(10):1–22.
15. Wang Q, Ren N, Cai Z, Lin Q, Wang Z, Zhang Q, et al. Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2. npj Park Dis [Internet]. 2017;3(1). Available from: http://dx.doi.org/10.1038/s41531-017-0033-1
16. Cicchetti F, Lapointe N, Roberge-Tremblay A. Systemic exposure to paraquat and maneb models early Parkinson’s disease in young adult rats. Neurobiol Dis. 2005;20(2):360–71.
17. Kumar A, Singh BK, Ahmad I, Shukla S, Patel DK, Srivastava G, et al. Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: Similarity with paraquat neurotoxicity. Brain Res [Internet]. 2012;1438:48–64. Available from: http://dx.doi.org/10.1016/j.brainres.2011.12.028.
18. Ellwanger JH, Molz P, Dallemole DR, Pereira dos Santos A, Müller TE, Cappelletti L, et al. Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson’s disease. Nutrition. 2015;31(2):359–65.
19. Srivastava G, Dixit A, Yadav S, Patel DK, Prakash O, Singh MP. Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse. Free Radic Biol Med [Internet]. 2012;52(8):1294–306. Available from: http://dx.doi.org/10.1016/j.freeradbiomed.2012.02.005.
20. Franco R, Li S, Rodriguez-Rocha H. Molecular Mechanisms of Pesticide-induced Neurotoxicity: Relevance to Parkinson’s Disease. Fieldiana Geol. 2010;289–300.
Published
2023-09-30
How to Cite
ATHIULLAH, Aulia Wahyu; NARWANTO, Muhammad Ihwan; RUSMATIKA, Nindya Shinta.
PAPARAN PARAKUAT TERHADAP REGULASI PROTEIN APOPTOSIS NEURON PADA SUBSTANTIA NIGRA MODEL PARKINSON: TINJAUAN SISTEMATIK.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 6, n. 3, p. 317-328, sep. 2023.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/423>. Date accessed: 03 july 2024.
Section
Articles
