DIABETES MELLITUS DAN GANGGUAN FUNGSI SEKSUAL
Abstract
Diabetes melitus (DM) adalah penyakit degeneratif yang banyak diderita oleh
masyarakat dan jumlah penderitanya cenderung semakin meningkat. DM mengakibatkan
berbagai hal yang merugikan terutama dapat menyebabkan penurunan atau kerusakan
fungsi organ maupun sistem tubuh. Gangguan fungsi seksual adalah salah satu
permasalahan kesehatan yang ditimbulkan oleh penyakit ini. Studi literatur dilakukan
untuk mengetahui beberapa gangguan fungsi seksual yang diakibatkan oleh penyakit
diabetes melitus. Penelusuran literatur dilakukan melalui basis data Pubmed dan NCBI.
Jumlah penderita penyakit DM cenderung meningkat. WHO memperkirakan sekitar 330
juta penduduk dunia yang menderita DM di tahun 2030. Pada tahun 2005, terdapat
sekitar 24 juta penderita DM di Indonesia. Gangguan fungsi seksual yang di timbulkan
oleh DM bisa di alami oleh pria maupun wanita, yaitu gangguan keinginan seksual,
gangguan bangkitan seksual dan gangguan ejakulasi pada pria. Gangguan keinginan
seksual terutama pada pria DM dikaitkan dengan penurunan kadar hormon testosteron.
Gangguan bangkitan seksual pada pria DM muncul berupa disfungsi ereksi dan berkaitan
dengan kerusakan endotel pembuluh darah dan kerusakan saraf perifer sedangkan
gangguan bangkitan seksual pada wanita berupa gangguan lubrikasi vagina. Gangguan
ejakulasi pada pria DM dapat muncul karena gangguan saraf otonom. Hal ini dapat
ditimbulkan oleh berbagai macam faktor antara lain metabolic insult terhadap serabut
saraf, insufisiensi neurovaskular, kerusakan autoimun, dan defisiensi neurohormonal
faktor pertumbuhan. Ejakulasi terbalik juga merupakan salah satu gangguan fungsi seksual
yang bisa ditimbulkan akibat DM.
References
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15. Pedersen M, Giraldi A, Kristensen E, Lauritzen T, Sandbæk A, Charles M. Prevalence of sexual desire and satisfaction among patients with screen-detected diabetes and impact of intensive multifactorial treatment: results from the ADDITION-Denmark study. Scand J Prim Health Care. 2015;33(1):3-10.
16. Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes. J Clin Endocrinol Metab. 2004;89(11):5462-8.
17. Madhu SV, Aslam M, Aiman AJ, Siddiqui A, Dwivedi S. Prevalence of hypogonadism in male Type 2 diabetes mellitus patients with and without coronary artery disease. Indian J Endocrinol Metab. 2017;21(1):31-7.
18. Afshari P, Yazdizadeh S, Abedi P, Rashidi H. The Relation of Diabetes Type 2 with Sexual Function among Reproductive Age Women in Iran, a Case-Control Study. Adv Med. 2017;2017:4838923-.
19. Wankeu-Nya M, Florea A, Bâlici Ş, Matei H, Watcho P, Kamanyi A. Cytoarchitectural improvement in Leydig cells of diabetic rats after treatment with aqueous and ethanol extracts of Dracaena arborea (Dracaenaceae). J Tradit Complement Med. 2019;11(1):1-8.
20. Kandeel FR, Koussa VK, Swerdloff RS. Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocrine reviews. 2001;22(3):342-88.
21. Vinik AI, Erbas T. Recognizing and treating diabetic autonomic neuropathy. Cleveland Clinic journal of medicine. 2001;68(11):928-30, 32, 34-44.
22. Brown J, Wessells H, Chancellor M, Howards S, Stamm W, Stapleton A, et al. Urologic Complications of Diabetes. Diabetes care. 2005;28(1).
23. Zheng H, Bidasee K, Mayhan W, Patel K. Lack of central nitric oxide triggers erectile dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol 2007;292(3).
24. Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity. Diabetes care. 2007;30(4):911-7.
25. De Berardis G, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, et al. Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes care. 2002;25(2):284-91.
26. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes care. 2003;26(5):1553-79.
27. Phé V, Rouprêt M. Erectile dysfunction and diabetes: a review of the current evidence-based medicine and a synthesis of the main available therapies. Diabetes & metabolism. 2012;38(1):1-13.
28. Francis SH, Corbin JD. PDE5 inhibitors: targeting erectile dysfunction in diabetics. Current opinion in pharmacology. 2011;11(6):683-8.
29. Shah PC, Trivedi NA. A meta-analysis on efficacy and tolerability of sildenafil for erectile dysfunction in patients with diabetes mellitus. Indian J Sex Transm Dis AIDS. 2018;39(1):1-6.
30. Bolat MS, Cinar O, Akdeniz E, Aşcı R. Low dose daily versus on-demand high dose tadalafil in diabetic patients with erectile and ejaculatory dysfunction. International journal of impotence research. 2018;30(3):102-7.
31. Meacham RB. Strategies for enhancing sperm survival in specimens obtained from patients with retrograde ejaculation. Journal of andrology. 2005;26(2):174-5.
32. Fedder J, Kaspersen, Brandslund I, Højgaard A. Retrograde ejaculation and sexual dysfunction in men with diabetes mellitus: a prospective, controlled study. Andrology. 2013;1(4).
33. Mostafa T, Abdel-Hamid I. Ejaculatory dysfunction in men with diabetes mellitus. World J Diabetes. 2021;12(7):954-74.
34. Taylor C. Review: Diabetes and assisted reproductive technology. Br J Diabetes Vasc Dis. 2002;2(4):247-53.
2. P2PTM Kemenkes RI. Lindungi Keluarga Dari Diabetes. Website [update 13/04/2018; sitasi 28/08/2021]. Available from: http://p2ptm.kemkes.go.id/post/lindungi-keluarga-dari-diabetes.
3. Pusdatin Kemenkes. Diabetes Melitus. Website [update 21/10/2020; sitasi 20/08/2021]. Available from: https://pusdatin.kemkes.go.id/article/view/20111800001/diabetes-melitus.html.
4. WHO. Sexual health 2021 [Available from: https://www.who.int/teams/sexual-and-reproductive-health-and-research/key-areas-of-work/sexual-health/defining-sexual-health.
5. Lloyd B, Williams R, Huber J. Erectile dysfunction and diabetes: A study in primary care. Br J Diabetes Vase Dis 2004;4:387-92.
6. Kouidrat Y, Pizzol D, Cosco T, Thompson T, Carnaghi M, Bertoldo A, et al. High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies. Diabetic medicine : a journal of the British Diabetic Association. 2017;34(9):1185-92.
7. De Berardis G, Pellegrini F, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, et al. Longitudinal assessment of quality of life in patients with type 2 diabetes and self-reported erectile dysfunction. Diabetes care. 2005;28(11):2637-43.
8. Elterman D, Bhattacharyya S, Mafilios M, Woodward E, Nitschelm K, Burnett A. The Quality of Life and Economic Burden of Erectile Dysfunction. Res Rep Urol. 2021;13:79-86.
9. Chen L, Shi GR, Huang DD, Li Y, Ma CC, Shi M, et al. Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019;112:108585.
10. APA. Diagnostic and statistical manual of mental health disorders. Website [update 01/10/2020; sitasi 20/08/2021]. Available from: https://www.psychiatry.org/psychiatrists/practice/dsm.
11. IsHak W, Mikhail A, Amiri R, Berman L, Vasa M. Sexual Dysfunction. Focus : journal of life long learning in psychiatry. 2005;3(4).
12. IsHak MDFW, Tobia G. DSM-5 Changes in Diagnostic Criteria of Sexual Dysfunctions. Reprod Sys Sexual Disorders. 2013;2:122.
13. Avasthi A, Grover S, Sathyanarayana Rao TS. Clinical Practice Guidelines for Management of Sexual Dysfunction. Indian J Psychiatry. 2017;59(Suppl 1):S91-S115.
14. Sapra A, P B. Diabetes Mellitus. Treasure Island (FL): StatPearls Publishing; 2021. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551501/.
15. Pedersen M, Giraldi A, Kristensen E, Lauritzen T, Sandbæk A, Charles M. Prevalence of sexual desire and satisfaction among patients with screen-detected diabetes and impact of intensive multifactorial treatment: results from the ADDITION-Denmark study. Scand J Prim Health Care. 2015;33(1):3-10.
16. Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes. J Clin Endocrinol Metab. 2004;89(11):5462-8.
17. Madhu SV, Aslam M, Aiman AJ, Siddiqui A, Dwivedi S. Prevalence of hypogonadism in male Type 2 diabetes mellitus patients with and without coronary artery disease. Indian J Endocrinol Metab. 2017;21(1):31-7.
18. Afshari P, Yazdizadeh S, Abedi P, Rashidi H. The Relation of Diabetes Type 2 with Sexual Function among Reproductive Age Women in Iran, a Case-Control Study. Adv Med. 2017;2017:4838923-.
19. Wankeu-Nya M, Florea A, Bâlici Ş, Matei H, Watcho P, Kamanyi A. Cytoarchitectural improvement in Leydig cells of diabetic rats after treatment with aqueous and ethanol extracts of Dracaena arborea (Dracaenaceae). J Tradit Complement Med. 2019;11(1):1-8.
20. Kandeel FR, Koussa VK, Swerdloff RS. Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocrine reviews. 2001;22(3):342-88.
21. Vinik AI, Erbas T. Recognizing and treating diabetic autonomic neuropathy. Cleveland Clinic journal of medicine. 2001;68(11):928-30, 32, 34-44.
22. Brown J, Wessells H, Chancellor M, Howards S, Stamm W, Stapleton A, et al. Urologic Complications of Diabetes. Diabetes care. 2005;28(1).
23. Zheng H, Bidasee K, Mayhan W, Patel K. Lack of central nitric oxide triggers erectile dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol 2007;292(3).
24. Kapoor D, Aldred H, Clark S, Channer KS, Jones TH. Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity. Diabetes care. 2007;30(4):911-7.
25. De Berardis G, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, et al. Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes care. 2002;25(2):284-91.
26. Vinik AI, Maser RE, Mitchell BD, Freeman R. Diabetic autonomic neuropathy. Diabetes care. 2003;26(5):1553-79.
27. Phé V, Rouprêt M. Erectile dysfunction and diabetes: a review of the current evidence-based medicine and a synthesis of the main available therapies. Diabetes & metabolism. 2012;38(1):1-13.
28. Francis SH, Corbin JD. PDE5 inhibitors: targeting erectile dysfunction in diabetics. Current opinion in pharmacology. 2011;11(6):683-8.
29. Shah PC, Trivedi NA. A meta-analysis on efficacy and tolerability of sildenafil for erectile dysfunction in patients with diabetes mellitus. Indian J Sex Transm Dis AIDS. 2018;39(1):1-6.
30. Bolat MS, Cinar O, Akdeniz E, Aşcı R. Low dose daily versus on-demand high dose tadalafil in diabetic patients with erectile and ejaculatory dysfunction. International journal of impotence research. 2018;30(3):102-7.
31. Meacham RB. Strategies for enhancing sperm survival in specimens obtained from patients with retrograde ejaculation. Journal of andrology. 2005;26(2):174-5.
32. Fedder J, Kaspersen, Brandslund I, Højgaard A. Retrograde ejaculation and sexual dysfunction in men with diabetes mellitus: a prospective, controlled study. Andrology. 2013;1(4).
33. Mostafa T, Abdel-Hamid I. Ejaculatory dysfunction in men with diabetes mellitus. World J Diabetes. 2021;12(7):954-74.
34. Taylor C. Review: Diabetes and assisted reproductive technology. Br J Diabetes Vasc Dis. 2002;2(4):247-53.
Published
2022-01-03
How to Cite
RIZAL, Dicky Moch.
DIABETES MELLITUS DAN GANGGUAN FUNGSI SEKSUAL.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 4, n. 5, p. 507-520, jan. 2022.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/204>. Date accessed: 30 oct. 2024.
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