MANFAAT AEROBIC EXERCISE TERHADAP KADAR BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) PADA STROKE SURVIVOR: SEBUAH TINJAUAN SISTEMATIS
Abstract
Gangguan kognitif sering terjadi pada penyintas stroke, berdampak besar pada kualitas hidup. Aerobic exercise terbukti dapat meningkatkan kadar Brain-Derived Neurotrophic Factor (BDNF), protein penting untuk neuroplastisitas, fungsi kognitif, dan pemulihan motorik. Kajian ini menggunakan tinjauan sistematis pada PubMed®, Cochrane®, ScienceDirect®, dan hand search dengan kriteria inklusi: penyintas stroke yang mendapat aerobic exercise, pengukuran BDNF, dan studi eksperimental. Hasil menunjukkan latihan aerobik intensitas tinggi secara signifikan meningkatkan BDNF dibandingkan intensitas sedang, rendah, atau latihan lain. Peningkatan BDNF berkorelasi positif dengan perbaikan fungsi kognitif, motorik, dan neuroplastisitas, menjadikan BDNF biomarker potensial dalam evaluasi rehabilitasi pascastroke. Latihan intensitas tinggi mendukung neuroplastisitas melalui peningkatan aliran darah otak, metabolisme oksigen, dan neurogenesis. Aerobic exercise, terutama intensitas tinggi, efektif meningkatkan BDNF, neuroplastisitas, dan fungsi kognitif serta motorik pada penyintas stroke. Temuan ini mendukung integrasi latihan aerobik intensitas tinggi dalam program rehabilitasi stroke untuk meningkatkan pemulihan dan kualitas hidup pasien.
Kata Kunci: aerobic exercise, Brain-Derived Neurotrophic Factor (BDNF), neuroplastisitas, rehabilitasi pascastroke, stroke
References
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17. Mojtabavi H, Shaka Z, Momtazmanesh S, Ajdari A, Rezaei N. Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis. J Transl Med [Internet]. 2022 Dec 1 [cited 2025 May 8];20(1):1–20. Available from: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03312-y
18. Morais VAC de, Tourino MF da S, Almeida AC de S, Albuquerque TBD, Linhares RC, Christo PP, et al. A single session of moderate intensity walking increases brain-derived neurotrophic factor (BDNF) in the chronic post-stroke patients*. Top Stroke Rehabil [Internet]. 2018 Jan 2 [cited 2025 May 8];25(1):1–5. Available from: https://www.tandfonline.com/doi/pdf/10.1080/10749357.2017.1373500
19. Sivaramakrishnan A, Subramanian SK. A Systematic Review on the Effects of Acute Aerobic Exercise on Neurophysiological, Molecular, and Behavioral Measures in Chronic Stroke. Neurorehabil Neural Repair [Internet]. 2023 Feb 1 [cited 2025 May 8];37(2–3):151–64. Available from: https://pubmed.ncbi.nlm.nih.gov/36703562/
20. Mackay CP, Brauer SG, Kuys SS, Schaumberg MA, Leow LA. The acute effects of aerobic exercise on sensorimotor adaptation in chronic stroke. Restor Neurol Neurosci [Internet]. 2021 [cited 2025 May 8];39(5):367–77. Available from: https://pubmed.ncbi.nlm.nih.gov/34569981/
2. Dian Saraswati R, Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan P. Transisi Epidemiologi Stroke sebagai Penyebab Kematian pada Semua Kelompok Usia di Indonesia. Seminar Nasional Riset Kedokteran [Internet]. 2021 Mar 16 [cited 2025 May 8];2(1):2021. Available from: https://conference.upnvj.ac.id/index.php/sensorik/article/view/1001
3. Direktorat Jenderal Kesehatan Lanjutan [Internet]. [cited 2025 May 8]. Available from: https://keslan.kemkes.go.id/read/1443/world-stroke-day-2023-greater-than-stroke-kenali-dan-kendalikan-stroke
4. Alcantara CC, García-Salazar LF, Silva-Couto MA, Santos GL, Reisman DS, Russo TL. Post-stroke BDNF concentration changes following physical exercise: A systematic review. Front Neurol [Internet]. 2018 Aug 28 [cited 2025 May 8];9(AUG). Available from: https://pubmed.ncbi.nlm.nih.gov/30210424/
5. Ashcroft SK, Ironside DD, Johnson L, Kuys SS, Thompson-Butel AG. Effect of Exercise on Brain-Derived Neurotrophic Factor in Stroke Survivors: A Systematic Review and Meta-Analysis. Stroke [Internet]. 2022 Dec 1 [cited 2025 May 8];53(12):3706–16. Available from: https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.122.039919?download=true
6. The effects of aerobic exercise intensity and duration on levels of brain-derived neurotrophic factor in healthy men - PubMed [Internet]. [cited 2025 May 8]. Available from: https://pubmed.ncbi.nlm.nih.gov/24149158/
7. Hsu CC, Fu TC, Huang SC, Chen CPC, Wang JS. Increased serum brain-derived neurotrophic factor with high-intensity interval training in stroke patients: A randomized controlled trial. Ann Phys Rehabil Med [Internet]. 2021 Jul 1 [cited 2025 May 8];64(4). Available from: https://pubmed.ncbi.nlm.nih.gov/32344098/
8. El-Tamawy MS, Abd-Allah F, Ahmed SM, Darwish MH, Khalifa HA. Aerobic exercises enhance cognitive functions and brain derived neurotrophic factor in ischemic stroke patients. NeuroRehabilitation [Internet]. 2014 [cited 2025 May 8];34(1):209–13. Available from: https://pubmed.ncbi.nlm.nih.gov/24284463/
9. Koroleva ES, Tolmachev I V., Alifirova VM, Boiko AS, Levchuk LA, Loonen AJM, et al. Serum bdnf’s role as a biomarker for motor training in the context of ar-based rehabilitation after ischemic stroke. Brain Sci [Internet]. 2020 Sep 1 [cited 2025 May 8];10(9):1–19. Available from: https://pubmed.ncbi.nlm.nih.gov/32916851/
10. Harnish SM, Rodriguez AD, Blackett DS, Gregory C, Seeds L, Boatright JH, et al. Aerobic Exercise as an Adjuvant to Aphasia Therapy: Theory, Preliminary Findings, and Future Directions. Clin Ther [Internet]. 2018 Jan 1 [cited 2025 May 8];40(1):35-48.e6. Available from: https://pubmed.ncbi.nlm.nih.gov/29277374/
11. Kim TG, Bae SH, Kim KY. Effects of Dual-Task Training with different Intensity of Aerobic Exercise on Cognitive Function and Neurotrophic Factors in Chronic Stroke Patients. Res J Pharm Technol [Internet]. 2019 Feb 28 [cited 2025 May 8];12(2):693–8. Available from: https://rjptonline.org/AbstractView.aspx?PID=2019-12-2-42
12. Aisyah V, Subagyo S, Subadi I. Effect of Aerobic Exercise on Brain-derived Neurotrophic Factor (BDNF) Serum Level in Stroke Subjects with Cognitive Function Impairment. Surabaya Physical Medicine and Rehabilitation Journal [Internet]. 2020 Aug 31 [cited 2025 May 8];2(2):42–8. Available from: https://e-journal.unair.ac.id/SPMRJ/article/view/17669
13. Moore SA, Hallsworth K, Jakovljevic DG, Blamire AM, He J, Ford GA, et al. Effects of Community Exercise Therapy on Metabolic, Brain, Physical, and Cognitive Function Following Stroke: A Randomized Controlled Pilot Trial. Neurorehabil Neural Repair [Internet]. 2015 Aug 23 [cited 2025 May 8];29(7):623–35. Available from: https://pubmed.ncbi.nlm.nih.gov/25538152/
14. Ferris LT, Williams JS, Shen CL. The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc [Internet]. 2007 Apr [cited 2025 May 8];39(4):728–34. Available from: https://pubmed.ncbi.nlm.nih.gov/17414812/
15. Albinet CT, Mandrick K, Bernard PL, Perrey S, Blain H. Improved cerebral oxygenation response and executive performance as a function of cardiorespiratory fitness in older women: A fNIRS study. Front Aging Neurosci [Internet]. 2014 Oct 8 [cited 2025 May 8];6(OCT):99994. Available from: www.frontiersin.org
16. Wang JS, Wu MH, Mao TY, Fu TC, Hsu CC. Effects of normoxic and hypoxic exercise regimens on cardiac, muscular, and cerebral hemodynamics suppressed by severe hypoxia in humans. J Appl Physiol [Internet]. 2010 Jul [cited 2025 May 8];109(1):219–29. Available from: https://pubmed.ncbi.nlm.nih.gov/20431021/
17. Mojtabavi H, Shaka Z, Momtazmanesh S, Ajdari A, Rezaei N. Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis. J Transl Med [Internet]. 2022 Dec 1 [cited 2025 May 8];20(1):1–20. Available from: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03312-y
18. Morais VAC de, Tourino MF da S, Almeida AC de S, Albuquerque TBD, Linhares RC, Christo PP, et al. A single session of moderate intensity walking increases brain-derived neurotrophic factor (BDNF) in the chronic post-stroke patients*. Top Stroke Rehabil [Internet]. 2018 Jan 2 [cited 2025 May 8];25(1):1–5. Available from: https://www.tandfonline.com/doi/pdf/10.1080/10749357.2017.1373500
19. Sivaramakrishnan A, Subramanian SK. A Systematic Review on the Effects of Acute Aerobic Exercise on Neurophysiological, Molecular, and Behavioral Measures in Chronic Stroke. Neurorehabil Neural Repair [Internet]. 2023 Feb 1 [cited 2025 May 8];37(2–3):151–64. Available from: https://pubmed.ncbi.nlm.nih.gov/36703562/
20. Mackay CP, Brauer SG, Kuys SS, Schaumberg MA, Leow LA. The acute effects of aerobic exercise on sensorimotor adaptation in chronic stroke. Restor Neurol Neurosci [Internet]. 2021 [cited 2025 May 8];39(5):367–77. Available from: https://pubmed.ncbi.nlm.nih.gov/34569981/
Published
2025-06-30
How to Cite
SUDARSONO, Nani Cahyani et al.
MANFAAT AEROBIC EXERCISE TERHADAP KADAR BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) PADA STROKE SURVIVOR: SEBUAH TINJAUAN SISTEMATIS.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 8, n. 2, p. 174-184, june 2025.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/1329>. Date accessed: 19 july 2025.
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Articles
