KORELASI INDEKS PLATELET DAN KADAR INTERLEUKIN-6 PADA PASIEN HIPERTENSI

  • Rini Roslaeni Departemen Patologi Klinik, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Hendri Priyadi Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Hindun Sa'adah Departemen Anatomi, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Linlin Haeni Departemen Histologi, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Desy Linasari Departemen Ilmu Kesehatan Masyarakat, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Laila Hasanah Program Studi Kedokteran, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Salma Syifa Salsabila Program Studi Kedokteran, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Rifat Budi Augustyo Isnaeni Program Studi Kedokteran, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia
  • Dika Kusuma Putra Program Studi Kedokteran, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia

Abstract

Mekanisme terjadinya hipertensi melibatkan proses inflamasi dan aktivasi sistem imun yang membentuk kondisi proinflamasi dan protrombotik, ditandai pelepasan reactive oxygen species (ROS). Kondisi tersebut menyebabkan disfungsi endotel, aterosklerosis dan pelepasan interleukin-6 (IL-6) yang pada akhirnya mempengaruhi fungsi platelet. Indeks platelet yang terdiri dari Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Large Cell Ratio (PLCR), dan Plateletcrit (PCT) dapat menjadi penanda aktivasi platelet dan inflamasi. Disisi lain, IL-6 juga merupakan sitokin inflamasi ang terlibat dalam berbagai penyakit. Tetapi, korelasi antara kedua parameter ini masih belum sepenuhnya dipahami. Penelitian ini bertujuan untuk mengetahui korelasi antara indeks platelet  dan kadar IL-6 pada pasien hipertensi. Subjek penelitian berjumlah 42 orang penderita hipertensi tanpa komplikasi. Pemeriksaan indeks platelet menggunakan alat hematology analyzer Maccura 560 Plus, sedangkan pemeriksaan IL-6 menggunakan mikroelisa. Hasil menunjukkan usia subjek rerata 57,8 ± 9,9 tahun, dan mayoritas perempuan 81%. Rerata sistolik 145,26 ± 15,02 mmHg dan diastolik 87,69 ± 11,55 mmHg. Rerata subjek lama menderita hipertensi 5,53 ± 4,24 tahun.  Rerata MPV 7,7 ± 0,7 fL, PDW 13,1 ± 1,73 fl, PCT 0,24 ± 0,05%, dan P-LCR 21,6 ± 5,59%. Kadar IL-6 rerata adalah 23,28 ± 2,70 pg/mL.  Tidak ditemukan korelasi signifikan antara indeks platelet dan kadar IL-6. Temuan ini mengindikasikan bahwa parameter-parameter tersebut mungkin tidak relevan dalam menggambarkan status inflamasi yang diwakili oleh kadar IL-6 dan indeks platelet pada populasi ini.


 


Kata Kunci: Hipertensi, Indeks platelet, Interleukin-6, MPV, PDW, PCT, P-LCR


DOI : 10.35990/mk.v8n1.p71-81

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Published
2025-03-31
How to Cite
ROSLAENI, Rini et al. KORELASI INDEKS PLATELET DAN KADAR INTERLEUKIN-6 PADA PASIEN HIPERTENSI. Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 8, n. 1, p. 71-81, mar. 2025. ISSN 2655-6537. Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/1272>. Date accessed: 16 may 2025.
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Vol 8 No 1 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
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