RASIO VISCERAL FAT TERHADAP BODY FAT PERCENTAGE DAN KORELASI LEMAH DENGAN KADAR HIGH DENSITY LIPOPROTEIN
Abstract
Pemeriksaan profil lipid dari serum sampai saat ini masih merupakan pemeriksaan yang digunakan untuk menentukan risiko terjadinya penyakit kardiovaskular di kemudian hari. Kadar High Density Lipoprotein (HDL) menggambarkan lipid yang berperan dalam mencegah terjadinya penyakit kardiovaskuler. Adipositas dalam pemeriksaan komposisi tubuh menggambarkan akumulasi lipid dalam jaringan, dan terdiri atas persentase lemak tubuh dan lemak visceral. Penelitian ini mempelajari korelasi antara kadar HDL serum dengan adipositas jaringan. Subyek penelitian merupakan subyek yang sehat, merupakan karyawan dari suatu institusi pendidikan dengan tingkat aktivitas fisik yang serupa. Pemeriksaan komposisi tubuh dilakukan dengan metode Bioimpedanceanalysis (BIA). Pemeriksaan kadar HDL dilakukan dari serum puasa dengan metode enzimatik kolorimetrik. Analisis korelasi dilakukan dengan Spearman correlation test dengan menggunakan program Statistical Package for Social Sciences (SPSS). Hasil penelitian menunjukkan bahwa subyek penelitian memiliki kadar HDL dalam kategori normal. Persentase lemak tubuh dan lemak visceral sebagian besar subyek penelitian berada dalam kategori normal, tinggi, dan sangat tinggi. Median kadar HDL adalah 49,00 mg/dL. Median dari rasio lemak visceral dan lemak tubuh total adalah 0,40. Korelasi antara kadar HDL dan rasio lemak visceral dan lemak tubuh total bermakna (P= 0,027) dengan koefisien korelasi sebesar - 0,4. Penelitian ini menunjukkan bahwa terdapat korelasi lemah antara adipositas jaringan yang ditunjukkan dengan rasio lemak viseral terhadap persentase lemak tubuh, dengan parameter lipid serum yaitu kadar HDL.
Kata kunci : adipositas, bioimpedance, body fat, HDL, visceral fat
References
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24.Katsuyama H, Kawaguchi A, Yanai H. Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects. Int J Cardiol. 2015;179:112-3.
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26.Fukuda T, Bouchi R, Takeuchi T, Nakano Y, Murakami M, Minami I, et al. Ratio of visceral-to-subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes. J Diabetes Investig. 2018;9(2):396-402.
27.Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64.
28.Bohm A, Heitmann BL. The use of bioelectrical impedance analysis for body composition in epidemiological studies. Eur J Clin Nutr. 2014;67 Suppl 1:S79-85.
29.Popiolek-Kalisz J, Szczygiel K. Bioelectrical Impedance Analysis and Body Composition in Cardiovascular Diseases. Curr Probl Cardiol. 2023;48(11):101911.
30.Threatte GA, Schexneider KI. Point-of-care and Physician Office Laboratories. In: A.McPherson R, Pincus. MR, editors. Henry’s clinical diagnosis and management by laboratory methods. 22 ed. Philadelphia: Elsevier SAunders; 2019. p. 73-9.
2. Li Y, Cao GY, Jing WZ, Liu J, Liu M. Global trends and regional differences in incidence and mortality of cardiovascular disease, 1990-2019: findings from 2019 global burden of disease study. Eur J Prev Cardiol. 2023;30(3):276-86.
3. Gonzalez-Juanatey C, Anguita-Sanchez M, Barrios V, Nunez-Gil I, Gomez-Doblas JJ, Garcia-Moll X, et al. Impact of Advanced Age on the Incidence of Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stable Coronary Artery Disease in a Real-World Setting in Spain. J Clin Med. 2023;12(16).
4. Amini M, Zayeri F, Salehi M. Trend analysis of cardiovascular disease mortality, incidence, and mortality-to-incidence ratio: results from global burden of disease study 2017. BMC Public Health. 2021;21(1):401.
5. Joseph P, Yusuf S. Coordinating Efforts to Reduce the Global Incidence of Cardiovascular Disease. N Engl J Med. 2023;389(14):1329-31.
6. Yokoyama H, Araki SI, Kawai K, Yamazaki K, Tomonaga O, Maeda H, et al. Reduced incidence of cardiovascular disease in patients with type 2 diabetes through the integrated improvement of diabetes care by comparing two prospective observational cohorts in real-world clinical practice (JDDM 72). Diabetes Res Clin Pract. 2023;202:110674.
7. Tang H, Xiang Z, Li L, Shao X, Zhou Q, You X, et al. Potential role of anti-inflammatory HDL subclasses in metabolic unhealth/obesity. Artif Cells Nanomed Biotechnol. 2021;49(1):565-75.
8. Thacker SG, Zarzour A, Chen Y, Alcicek MS, Freeman LA, Sviridov DO, et al. High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation. Immunology. 2016;149(3):306-19.
9. Silva AM, Campa F, Stagi S, Gobbo LA, Buffa R, Toselli S, et al. The bioelectrical impedance analysis (BIA) international database: aims, scope, and call for data. Eur J Clin Nutr. 2023;77(12):1143-50.
10. Moonen H, Van Zanten ARH. Bioelectric impedance analysis for body composition measurement and other potential clinical applications in critical illness. Curr Opin Crit Care. 2021;27(4):344-53.
11.Nagai M, Komiya H, Mori Y, Ohta T, Kasahara Y, Ikeda Y. Estimating visceral fat area by multifrequency bioelectrical impedance. Diabetes Care. 2014;33(5):1077-9.
12.Ward LC. Bioelectrical impedance analysis for body composition assessment: reflections on accuracy, clinical utility, and standardisation. Eur J Clin Nutr. 2019;73(2):194-9.
13.Kaess BM, Pedley A, Massaro JM, Murabito J, Hoffmann U, Fox CS. The ratio of visceral to subcutaneous fat, a metric of body fat distribution, is a unique correlate of cardiometabolic risk. Diabetologia. 2014;55(10):2622-30.
14.Kwon S, Han AL. The Correlation between the Ratio of Visceral Fat Area to Subcutaneous Fat Area on Computed Tomography and Lipid Accumulation Product as Indexes of Cardiovascular Risk. J Obes Metab Syndr. 2019;28(3):186-93.
15.Oh YH, Moon JH, Kim HJ, Kong MH. Visceral-to-subcutaneous fat ratio as a predictor of the multiple metabolic risk factors for subjects with normal waist circumference in Korea. Diabetes Metab Syndr Obes. 2017;10:505-11.
16.von Eckardstein A, Nordestgaard BG, Remaley AT, Catapano AL. High-density lipoprotein revisited: biological functions and clinical relevance. Eur Heart J. 2023;44(16):1394-407.
17.Byambasukh O, Eisenga MF, Gansevoort RT, Bakker SJ, Corpeleijn E. Body fat estimates from bioelectrical impedance equations in cardiovascular risk assessment: The PREVEND cohort study. Eur J Prev Cardiol. 2019;26(9):905-16.
18.Jung JH, Jung MK, Kim KE, Kwon AR, Chae HW, Yoon CS, et al. Ultrasound measurement of pediatric visceral fat thickness: correlations with metabolic and liver profiles. Ann Pediatr Endocrinol Metab. 2016;21(2):75-80.
19.Schlecht I, Wiggermann P, Behrens G, Fischer B, Koch M, Freese J, et al. Reproducibility and validity of ultrasound for the measurement of visceral and subcutaneous adipose tissues. Metabolism. 2014;63(12):1512-9.
20.Pinho CPS, Diniz ADS, de Arruda IKG, Leite A, Petribu MMV, Rodrigues IG. Predictive models for estimating visceral fat: The contribution from anthropometric parameters. PLoS One. 2017;12(7):e0178958.
21.Higuchi S, Kabeya Y, Kato K. Visceral-to-subcutaneous fat ratio is independently related to small and large cerebrovascular lesions even in healthy subjects. Atherosclerosis. 2017;259:41-5.
22.Jung CH, Rhee EJ, Kwon H, Chang Y, Ryu S, Lee WY. Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis. Endocrinol Metab (Seoul). 2020;35(1):165-76.
23.Kataoka H, Mochizuki T, Iwadoh K, Ushio Y, Kawachi K, Watanabe S, et al. Visceral to subcutaneous fat ratio as an indicator of a >/=30% eGFR decline in chronic kidney disease. PLoS One. 2020;15(11):e0241626.
24.Katsuyama H, Kawaguchi A, Yanai H. Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects. Int J Cardiol. 2015;179:112-3.
25.Chen KL, Chou RH, Chang CC, Kuo CS, Wei JH, Huang PH, et al. The high-density lipoprotein cholesterol (HDL-C)-concentration-dependent association between anti-inflammatory capacity and sepsis: A single-center cross-sectional study. PLoS One. 2024;19(4):e0296863.
26.Fukuda T, Bouchi R, Takeuchi T, Nakano Y, Murakami M, Minami I, et al. Ratio of visceral-to-subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes. J Diabetes Investig. 2018;9(2):396-402.
27.Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64.
28.Bohm A, Heitmann BL. The use of bioelectrical impedance analysis for body composition in epidemiological studies. Eur J Clin Nutr. 2014;67 Suppl 1:S79-85.
29.Popiolek-Kalisz J, Szczygiel K. Bioelectrical Impedance Analysis and Body Composition in Cardiovascular Diseases. Curr Probl Cardiol. 2023;48(11):101911.
30.Threatte GA, Schexneider KI. Point-of-care and Physician Office Laboratories. In: A.McPherson R, Pincus. MR, editors. Henry’s clinical diagnosis and management by laboratory methods. 22 ed. Philadelphia: Elsevier SAunders; 2019. p. 73-9.
Published
2024-12-31
How to Cite
SUSANTI, Anita Liliana et al.
RASIO VISCERAL FAT TERHADAP BODY FAT PERCENTAGE DAN KORELASI LEMAH DENGAN KADAR HIGH DENSITY LIPOPROTEIN.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 7, n. 4, p. 387-397, dec. 2024.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/1181>. Date accessed: 25 jan. 2025.
Section
Articles
