ANTIBACTERIAL POTENTIAL OF DAYAK ONION BULB EXTRACT (Eleutherine sp) AS A TREATMENT FOR ACNE VULGARIS: A LITERATURE REVIEW
Abstract
Acne vulgaris is a common skin disorder that can significantly affect quality of life. Although conventional antibiotic treatments are commonly used, herbal alternatives such as Eleutherine sp. (Dayak onion) bulb extract may offer therapeutic options for acne vulgaris. This study is a literature review that evaluates the antibacterial activity of Dayak onion bulb extract against bacteria that cause acne vulgaris. The search was conducted in the ScienceDirect, PubMed, Google Scholar, and Garuda databases, focusing on in vitro studies published in the last 10 years. Of the 8 articles analyzed, Dayak onion bulb extract was effective against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes. The best antibacterial activity was obtained from extracts at high concentrations with several methods. Temperature and incubation duration also affected the results. Active compounds such as flavonoids, alkaloids, triterpenoids, steroids, and tannins contributed to the antibacterial effectiveness of this extract. Dayak onion bulb extract showed strong antibacterial effectiveness, making it a potential alternative for treating acne vulgaris. This extract as an additional therapy offers a safe option as a natural acne vulgaris treatment solution.
Keywords: acne vulgaris, antibacterial, Eleutherine
References
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19. Prayekti E, Prayoga MA. Pengujian Stabilitas Antibakteri Terhadap Staphylococcus aureus Dari Eksrak Etanol Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) Dengan Perlakuan Suhu Penyimpanan. BIOSAPPHIRE: Jurnal Biologi dan Diversitas. 2022;1(2):61–6.
20. Yuan G, Guan Y, Yi H, Lai S, Sun Y, Cao S. Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities. Sci Rep. 2021;11(1):10471.
21. Lobiuc A, Pavăl NE, Mangalagiu II, Gheorghiță R, Teliban GC, Amăriucăi-Mantu D, et al. Future antimicrobials: Natural and functionalized phenolics. Molecules. 2023;28(3):1114.
22. Ardhany SD, Effendie RR, Novaryatiin S. Uji Iritasi Formulasi Sediaan Krim Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) pada Kelinci Albino Putih: Irritation Test of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) Extract Cream Formulation in White Albino Rabbits. Jurnal Surya Medika (JSM). 2019;5(1):63–9.
23. Ardhany SD, Novaryatiin S, Pratama MRF, Utar Z. Irritation test of Bawang Dayak (Eleutherine Bulbosa (Mill.) Urb.) extract cream with human patch test method. Jurnal Farmasi Sains dan Praktis. 2021;7(1):74–80.
24. Agustin E, Yanti N. Formulasi dan Evaluasi Ekstrak Bawang Dayak (Eleutherine palmifolia L. Merr) dalam Sediaan Gel sebagai Anti Jerawat: Formulation and Evaluation of Dayak Union Extract (Eleutherine palmifolia L. Merr) in Gel Preparations as Antiacne. Jurnal Sains dan Kesehatan. 2023;5(5):751–8.
25. Kartikasari D, Anggraini R. Formulasi masker gel peel off dari ekstrak etanol umbi bawang dayak (Eleutherinebulbosa (Mill.) Urb. Eleutherine Americana Merr). Jurnal Ilmu Farmasi dan Farmasi Klinik. 2018;15(01):1–11.
2. Hay RJ, Johns NE, Williams HC, Bolliger IW, Dellavalle RP, Margolis DJ, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. Journal of investigative dermatology. 2014;134(6):1527–34.
3. Chen H, Zhang TC, Yin XL, Man JY, Yang XR, Lu M. Magnitude and temporal trend of acne vulgaris burden in 204 countries and territories from 1990 to 2019: an analysis from the Global Burden of Disease Study 2019. Br J Dermatol. 2022;186(4):673–83.
4. Kumar B, Pathak R, Mary PB, Jha D, Sardana K, Gautam HK. New insights into acne pathogenesis: Exploring the role of acne-associated microbial populations. Dermatologica Sinica. 2016;34(2):67–73.
5. Reynolds R V, Yeung H, Cheng CE, Cook-Bolden F, Desai SR, Druby KM, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol . 2024;90(5):1006.e1-1006.e30.
6. Kuntorini E. Anatomical structure and antioxidant activity of red bulb plant (Eleutherine americana) on different plant age. Biodiversitas. 2016 May 1;17:229–33.
7. Harlita TD, Asnani A. The antibacterial activity of dayak onion (Eleutherine palmifolia (L.) merr) towards pathogenic bacteria. Trop Life Sci Res. 2018;29(2):39.
8. Muti’ah R, Listiyana A, Nafisa BB, Suryadinata A. Kajian efek ekstrak umbi bawang dayak (Eleutherine palmifolia (L.) Merr) sebagai antikanker. Journal of Islamic Pharmacy. 2020;5(2):14–25.
9. Shi P, Du W, Wang Y, Teng X, Chen X, Ye L. Total phenolic, flavonoid content, and antioxidant activity of bulbs, leaves, and flowers made from Eleutherine bulbosa (Mill.) Urb. Food Sci Nutr. 2019;7(1):148–54.
10. Kamarudin AA, Sayuti NH, Saad N, Razak NAA, Esa NM. Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the pharmacological activities and its prospects for application. Int J Mol Sci. 2021;22(13):6747.
11. Milliana A, Listiyana A, Mutiah R, Annisa R, Firdausi AF, Faradila VA, et al. The Potential of Eleutherine bulbosa in Inducing Apoptosis and Inhibiting Cell Cycle in Breast Cancer: A Network Pharmacology Approach and In Vitro Experiments. Asian Pac J Cancer Prev. 2023;24(11):3783.
12. Novaryatiin S, Ardhany SD. Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan-Indonesia. Pharmacognosy Journal. 2020 Feb 10;12:52–7.
13. Fitriyanti F, Abdurrazaq A, Nazarudin M. Uji efektivitas antibakteri esktrak etil asetat bawang dayak (eleutherine palmifolia merr) terhadap staphylococcus aureus dengan metode sumuran. Jurnal Ilmiah Manuntung. 2019;5(2):174–82.
14. Warsiti W, Wardani SD, Ramadhan AA, Yuliani R. Uji Aktivitas Antibakteri Ekstrak Etanol Bawang Dayak (Eleutherine palmifolia (L.) Merr) Terhadap Bakteri Staphylococcus aureus. Pharmacon: Jurnal Farmasi Indonesia. 2019;15(2):75–82.
15. Putri RA, Simbala HEI, Mpila DA. Uji Aktivitas Antibakteri Ekstrak Etanol Bawang Dayak (Eleutherine americana Merr) Terhadap Bakteri Staphylococcus aureus, Escherichia coli dan Salmonella typhi. PHARMACON . 2020;
16. Chandra MA, Pambudi DR, Fitriyanti, Kholilah S, Jamalludin W Bin. Effect of differences in solvent ethanol extract of dayak onion bulbs and incubation time of Propionibacterium acneson the antibacterial activity test. Jurnal Ilmiah Farmasi. 2023;65–75.
17. Pambudi DR, Fitriyanti F, Kholilah S, Jamalludin W Bin, Chandra M. Pengaruh Masa Inkubasi Bakteri Propionibacterium acnes terhadap Aktivitas Antibakteri Ekstrak Etanol 96% Umbi Bawang Dayak (Eleutherine americana Merr.). Jurnal Pharmascience. 2023;
18. Fitriyanti F, Ridha A, Ramadhan H. Daya Antibakteri Ekstrak Etanol 96% Umbi Bawang Dayak (Eleutherine Americana Merr.) Terhadap Bakteri Propionibacterium acnes. Lumbung Farmasi: Jurnal Ilmu Kefarmasian. 2023;4(2):265–72.
19. Prayekti E, Prayoga MA. Pengujian Stabilitas Antibakteri Terhadap Staphylococcus aureus Dari Eksrak Etanol Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) Dengan Perlakuan Suhu Penyimpanan. BIOSAPPHIRE: Jurnal Biologi dan Diversitas. 2022;1(2):61–6.
20. Yuan G, Guan Y, Yi H, Lai S, Sun Y, Cao S. Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities. Sci Rep. 2021;11(1):10471.
21. Lobiuc A, Pavăl NE, Mangalagiu II, Gheorghiță R, Teliban GC, Amăriucăi-Mantu D, et al. Future antimicrobials: Natural and functionalized phenolics. Molecules. 2023;28(3):1114.
22. Ardhany SD, Effendie RR, Novaryatiin S. Uji Iritasi Formulasi Sediaan Krim Ekstrak Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) pada Kelinci Albino Putih: Irritation Test of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb) Extract Cream Formulation in White Albino Rabbits. Jurnal Surya Medika (JSM). 2019;5(1):63–9.
23. Ardhany SD, Novaryatiin S, Pratama MRF, Utar Z. Irritation test of Bawang Dayak (Eleutherine Bulbosa (Mill.) Urb.) extract cream with human patch test method. Jurnal Farmasi Sains dan Praktis. 2021;7(1):74–80.
24. Agustin E, Yanti N. Formulasi dan Evaluasi Ekstrak Bawang Dayak (Eleutherine palmifolia L. Merr) dalam Sediaan Gel sebagai Anti Jerawat: Formulation and Evaluation of Dayak Union Extract (Eleutherine palmifolia L. Merr) in Gel Preparations as Antiacne. Jurnal Sains dan Kesehatan. 2023;5(5):751–8.
25. Kartikasari D, Anggraini R. Formulasi masker gel peel off dari ekstrak etanol umbi bawang dayak (Eleutherinebulbosa (Mill.) Urb. Eleutherine Americana Merr). Jurnal Ilmu Farmasi dan Farmasi Klinik. 2018;15(01):1–11.
Published
2025-12-31
How to Cite
PRADHEA, Tifani Antonia et al.
ANTIBACTERIAL POTENTIAL OF DAYAK ONION BULB EXTRACT (Eleutherine sp) AS A TREATMENT FOR ACNE VULGARIS: A LITERATURE REVIEW.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 8, n. 4, p. 446-457, dec. 2025.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/1127>. Date accessed: 07 jan. 2026.
Section
Articles
