HIGH FLOW NASAL CANUL (HFNC) SEBAGAI TERAPI OKSIGEN PADA KASUS GAGAL NAFAS TIPE 1
Abstract
Penggunaan ventilasi mekanik invasif dapat meningkatkan morbiditas dan mortalitas terkait stres pulmonal dan pneumonia, serta mendorong penggunaan ventilasi non-invasif seperti High Flow Nasal Cannula (HFNC) sebagai terapi oksigen yang efektif pada gagal napas tipe 1. Studi ini bertujuan untuk menganalisis efektivitas HFNC dalam menangani gagal napas akut. Hasil penelitian menunjukkan bahwa HFNC mampu memberikan oksigen dengan konsentrasi tinggi dan aliran gas yang stabil, meningkatkan oksigenasi tanpa menimbulkan efek samping signifikan. HFNC juga terbukti meningkatkan kenyamanan pasien, mengurangi kebutuhan intubasi, dan memperbaiki hasil klinis secara keseluruhan. Kesimpulan dari penelitian ini adalah bahwa HFNC merupakan alternatif yang efektif dan aman dibandingkan dengan ventilasi mekanik invasif untuk pasien dengan gagal napas tipe 1.
Kata kunci: gagal napas akut, high flow nasal cannula, terapi oksigen, ventilasi non-invasif
References
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20. Messika J, Ben Ahmed K, Gaudry S, Miguel-Montanes R, Rafat C, Sztrymf B, et al. Use of High-Flow Nasal Cannula Oxygen Therapy in Subjects With ARDS: A 1-Year Observational Study. Respir Care. 2015 Feb;60(2):162–9.
21. Frat JP, Brugiere B, Ragot S, Chatellier D, Veinstein A, Goudet V, et al. Sequential Application of Oxygen Therapy Via High-Flow Nasal Cannula and Noninvasive Ventilation in Acute Respiratory Failure: An Observational Pilot Study. Respir Care. 2015 Feb;60(2):170–8.
22. Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure. New England Journal of Medicine. 2015 Jun 4;372(23):2185–96.
23. Kang BJ, Koh Y, Lim CM, Huh JW, Baek S, Han M, et al. Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med. 2015 Apr 18;41(4):623–32.
2. Renda T, Corrado A, Iskandar G, Pelaia G, Abdalla K, Navalesi P. High-flow nasal oxygen therapy in intensive care and anaesthesia. Br J Anaesth. 2018 Jan;120(1):18–27.
3. Nishimura M. High-flow nasal cannula oxygen therapy in adults. J Intensive Care. 2015 Dec 31;3(1):15.
4. Ricard JD, Roca O, Lemiale V, Corley A, Braunlich J, Jones P, et al. Use of nasal high flow oxygen during acute respiratory failure. Intensive Care Med. 2020 Dec 8;46(12):2238–47.
5. Mirabile VS, Shebl E, Sankari A, Burns B. Respiratory Failure in Adults. Treasure Island (FL): StatPearls Publishing. 2023.
6. Hanif H, Semedi BP, Utariani A. Laporan Kasus : PERAWATAN GAGAL NAPAS AKUT AKIBAT PNEUMONITIS LUPUS DI UNIT PERAWATAN INTENSIF DENGAN FASILITAS TERBATAS. Majalah Kesehatan. 2020 Mar 30;7(1):48–58.
7. Makdee O, Monsomboon A, Surabenjawong U, Praphruetkit N, Chaisirin W, Chakorn T, et al. High-Flow Nasal Cannula Versus Conventional Oxygen Therapy in Emergency Department Patients With Cardiogenic Pulmonary Edema: A Randomized Controlled Trial. Ann Emerg Med. 2017 Oct;70(4):465-472.e2.
8. Wang Q, Peng Y, Xu S, Lin L, Chen L, Lin Y. The efficacy of high-flow nasal cannula (HFNC) versus non-invasive ventilation (NIV) in patients at high risk of extubation failure: a systematic review and meta-analysis. Eur J Med Res. 2023 Mar 14;28(1):120.
9. Baillard C, Prat G, Jung B, Futier E, Lefrant JY, Vincent F, et al. Effect of preoxygenation using non-invasive ventilation before intubation on subsequent organ failures in hypoxaemic patients: a randomised clinical trial. Br J Anaesth. 2018 Feb;120(2):361–7.
10. Elhidsi M, Susanto AD, Prasenohadi, Rasmin M. TERAPI OKSIGEN KANULA HIDUNG ARUS TINGGI PADA GAGAL NAPAS AKUT PASIEN DEWASA. 1st ed. Jakarta: PDPI; 2021.
11. Nishimura M. High-Flow Nasal Cannula Oxygen Therapy in Adults: Physiological Benefits, Indication, Clinical Benefits, and Adverse Effects. Respir Care. 2016 Apr 25;61(4):529–41.
12. Pirret AM, Takerei SF, Matheson CL, Kelly M, Strickland W, Harford J, et al. Nasal high flow oxygen therapy in the ward setting: A prospective observational study. Intensive Crit Care Nurs. 2017 Oct;42:127–34.
13. Creagh-Brown B. Respiratory failure. Medicine. 2016 Jun;44(6):342–5.
14. Scala R, Heunks L. Highlights in acute respiratory failure. European Respiratory Review. 2018 Mar 31;27(147):180008.
15. Azoulay E, Pickkers P, Soares M, Perner A, Rello J, Bauer PR, et al. Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study. Intensive Care Med. 2017 Dec 25;43(12):1808–19.
16. Delorme M, Bouchard PA, Simon M, Simard S, Lellouche F. Effects of High-Flow Nasal Cannula on the Work of Breathing in Patients Recovering From Acute Respiratory Failure*. Crit Care Med. 2017 Dec;45(12):1981–8.
17. Carlucci A, Maggiore SM. High Flow Nasal Cannula. Carlucci A, Maggiore SM, editors. Cham: Springer International Publishing; 2021.
18. Frat JP, Ricard JD, Quenot JP, Pichon N, Demoule A, Forel JM, et al. Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial. Lancet Respir Med. 2019 Apr;7(4):303–12.
19. Sztrymf B, Messika J, Bertrand F, Hurel D, Leon R, Dreyfuss D, et al. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med. 2011 Nov 27;37(11):1780–6.
20. Messika J, Ben Ahmed K, Gaudry S, Miguel-Montanes R, Rafat C, Sztrymf B, et al. Use of High-Flow Nasal Cannula Oxygen Therapy in Subjects With ARDS: A 1-Year Observational Study. Respir Care. 2015 Feb;60(2):162–9.
21. Frat JP, Brugiere B, Ragot S, Chatellier D, Veinstein A, Goudet V, et al. Sequential Application of Oxygen Therapy Via High-Flow Nasal Cannula and Noninvasive Ventilation in Acute Respiratory Failure: An Observational Pilot Study. Respir Care. 2015 Feb;60(2):170–8.
22. Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, et al. High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure. New England Journal of Medicine. 2015 Jun 4;372(23):2185–96.
23. Kang BJ, Koh Y, Lim CM, Huh JW, Baek S, Han M, et al. Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med. 2015 Apr 18;41(4):623–32.
Published
2025-09-30
How to Cite
NUSWANTORO, Yulian et al.
HIGH FLOW NASAL CANUL (HFNC) SEBAGAI TERAPI OKSIGEN PADA KASUS GAGAL NAFAS TIPE 1.
Medika Kartika : Jurnal Kedokteran dan Kesehatan, [S.l.], v. 8, n. 3, p. 331-343, sep. 2025.
ISSN 2655-6537.
Available at: <http://medikakartika.unjani.ac.id/medikakartika/index.php/mk/article/view/1024>. Date accessed: 08 oct. 2025.
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Articles
